Title: Lessons from a failed ?-Secretase Alzheimer trial
Authors: De Strooper, Bart # ×
Issue Date: Nov-2014
Publisher: MIT Press
Series Title: Cell vol:159 issue:4 pages:721-6
Article number: 10.1016/j.cell.2014.10.016
Abstract: ?-Secretase proteases have been associated with pathology in Alzheimer disease (AD), but we are just beginning to understand their basic mechanisms and physiological roles. A negative drug trial with a broad spectrum ?-secretase inhibitor in AD patients has severely dampened enthusiasm for the potential of pursuing ?-secretase research therapeutically. This pessimism is unwarranted: analysis of available information presented here demonstrates significant confounds for interpreting the outcome of the trial and argues that the major lessons pertain to broad knowledge gaps that are imperative to fill.
ISSN: 0092-8674
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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