HIF1α is an independent prognostic factor for overall survival in advanced primary epithelial ovarian cancer - a study of the OVCAD Consortium
Braicu, Elena Ioana × Luketina, Hrvoje Richter, Rolf Cacsire Castillo-Tong, Dan Lambrechts, Sandrina Mahner, Sven Concin, Nicole Mentze, Monika Zeillinger, Robert Vergote, Ignace Sehouli, Jalid #
OncoTargets and Therapy vol:7 pages:1563-9
Hypoxia is a common phenomenon encountered in solid cancers, leading to chemotherapy resistance and therefore to aggressiveness of the disease. The homeostatic response to hypoxia is mediated by hypoxiainducible factor-1 (HIF-1). The aim of this study was to investigate the impact of HIF1α in patients with primary epithelial ovarian cancer.