Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study); a multicenter randomized placebo controlled trial
Onland, Wes × Offringa, Martin Cools, Filip De Jaegere, Anne P Rademaker, Karin Blom, Henry Cavatorta, Eric Debeer, Anne Dijk, Peter H van Heijst, Arno F Kramer, Boris W Kroon, Andre A Mohns, Thilo van Straaten, Henrica L te Pas, Arjan B Theyskens, Claire van Weissenbruch, Mirjam M van Kaam, Anton H #
BMC Pediatrics vol:11 pages:102
Randomized controlled trials have shown that treatment of chronically ventilated preterm infants after the first week of life with dexamethasone reduces the incidence of the combined outcome death or bronchopulmonary dysplasia (BPD). However, there are concerns that dexamethasone may increase the risk of adverse neurodevelopmental outcome. Hydrocortisone has been suggested as an alternative therapy. So far no randomized controlled trial has investigated its efficacy when administered after the first week of life to ventilated preterm infants.