Exacerbations in patients with chronic obstructive pulmonary disease receiving physical therapy: a cohort-nested randomised controlled trial
Beekman, Emmylou × Mesters, Ilse Hendriks, Erik J M Muris, Jean W M Wesseling, Geertjan Evers, Silvia M A A Asijee, Guus M Fastenau, Annemieke Hoffenkamp, Hannah N Gosselink, Rik van Schayck, Onno C P de Bie, Rob A #
BMC Pulmonary Medicine vol:14 issue:71 pages:1-14
Physical exercise training aims at reducing disease-specific impairments and improving quality of life in patients with chronic obstructive pulmonary disease (COPD). COPD exacerbations in particular negatively impact COPD progression. Physical therapy intervention seems indicated to influence exacerbations and their consequences. However, information on the effect of physical therapy on exacerbation occurrence is scarce. This study aims to investigate the potential of a protocol-directed physical therapy programme as a means to prevent or postpone exacerbations, to shorten the duration or to decrease the severity of exacerbations in patients with COPD who have recently experienced an exacerbation. Besides, this study focuses on the effect of protocol-directed physical therapy on health status and quality of life and on cost-effectiveness and cost-utility in patients with COPD who have recently experienced an exacerbation.