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Title: Evolutionary conservation and divergence of cis-regulatory interactions in Drosophila eye development
Other Titles: Evolutionaire conservatie en divergentie van cis-regulerende interacties tijdens de ontwikkeling van het Drosophila oog
Authors: Naval Sanchez, Marina
Issue Date: 20-Nov-2014
Table of Contents: CHAPTER I: INTRODUCTION: 1
Transcriptional Regulation: 1
Computational methods for CRM discovery: 4
Detecting regulatory elements by high-throughput methods: 10
Gene Regulatory Evolution:15
Drosophila eye development as a model system : 20
CHAPTER II: AIMS: 25
CHAPTER III:RESULTS : 27
I: Comparative motif discovery combined with comparative transcriptomics yields accurate targetome and enhancer predictions : 29
II: Application of Ornstein-Uhlenbeck models on phylogenetic trees to identify evolutionary changes in cis-regulatory sequences, enhancer chromatin activity and gene expression levels : 89
CHAPTER IV: DISCUSSION: 131
REFERENCES : 139
RESUME: 155
Publication status: published
KU Leuven publication type: TH
Appears in Collections:Laboratory of Computational Biology
Department of Human Genetics - miscellaneous

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