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Title: Effect of milrinone analogues on intracellular calcium increase in single living H9C2 cardiac cells
Authors: Pietrangelo, Tiziana
Giampietro, Letizia
De Filippis, Barbara
La Rovere, Rita
Fulle, Stefania
Amoroso, Rosa # ×
Issue Date: Nov-2010
Series Title: European Journal of Medicinal Chemistry vol:45 issue:11 pages:4928-33
Article number: 10.1016/j.ejmech.2010.08.001
Abstract: The synthesis of milrinone analogues where the 4-pyridyl moiety was replaced by an ester or amide group is reported. Only amide derivatives are able to support intracellular calcium influx following chemical depolarization with 60 mM KCl in a percentage varying from 20 to 45% of differentiated H9C2 cardiomyocytes. Those cells were differentiated after chronic exposure to 10 nM retinoic acid which induces the expression of voltage-gated calcium channels. Analogues of milrinone containing an ester function did not show significant activity.
ISSN: 0223-5234
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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