Title: Overview of clinical efficacy and risk data of benzodiazepines for prolonged seizures
Authors: Lagae, Lieven # ×
Issue Date: Oct-2014
Series Title: Epileptic Disorders vol:16 Suppl 1 pages:44-9
Article number: 10.1684/epd.2014.0687
Abstract: An historical overview is provided regarding the use of benzodiazepines for the treatment of acute prolonged convulsive seizures. It is clear that intravenous benzodiazepines remain a first step for the in-hospital treatment of prolonged seizures or status epilepticus. However, in the community, in a pre-hospital situation, intravenous administration is not possible. In recent years, it was shown that rectal, buccal, intranasal, and intramuscular administration of benzodiazepines is very effective as a first and safe treatment step. In many cases, rectal diazepam is not socially acceptable anymore, and therefore more emphasis is now put on buccal, intranasal, and intramuscular administration. At present, based on the available data, midazolam is the product of choice for the acute treatment of prolonged convulsive seizures.
ISSN: 1294-9361
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Brain & Metabolism Section (-)
Organ Systems (+)
× corresponding author
# (joint) last author

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