Pathogenic Ischemic Stroke Phenotypes in the NINDS-Stroke Genetics Network

Ay, Hakan; Arsava, Ethem Murat; Andsberg, Gunnar; Benner, Thomas; Brown, Robert D; Chapman, Sherita N; Cole, John W; Delavaran, Hossein; Dichgans, Martin; Engström, Gunnar; Giralt-Steinhauer, Eva; Grewal, Raji P; Gwinn, Katrina; Jern, Christina; Jimenez-Conde, Jordi; Jood, Katarina; Katsnelson, Michael; Kissela, Brett; Kittner, Steven J; Kleindorfer, Dawn O; Labovitz, Daniel L; Lanfranconi, Silvia; Lee, Jin-Moo; Lehm, Manuel; Lemmens, Robin; Levi, Chris; Li, Linxin; Lindgren, Arne; Markus, Hugh S; McArdle, Patrick F; Melander, Olle; Norrving, Bo; Peddareddygari, Leema Reddy; Pedersén, Annie; Pera, Joanna; Rannikmäe, Kristiina; Rexrode, Kathryn M; Rhodes, David; Rich, Stephen S; Roquer, Jaume; Rosand, Jonathan; Rothwell, Peter M; Rundek, Tatjana; Sacco, Ralph L; Schmidt, Reinhold; Schürks, Markus; Seiler, Stephan; Sharma, Pankaj; Slowik, Agnieszka; Sudlow, Cathie; Thijs, Vincent; Woodfield, Rebecca; Worrall, Bradford B; Meschia, James F

doi:10.1161/STROKEAHA.114.007362

Pathogenic Ischemic Stroke Phenotypes in the NINDS-Stroke Genetics Network

Author:

Ay, Hakan

Arsava, Ethem Murat ; Andsberg, Gunnar ; Benner, Thomas ; Brown, Robert D ; Chapman, Sherita N ; Cole, John W ; Delavaran, Hossein ; Dichgans, Martin ; Engström, Gunnar ; Giralt-Steinhauer, Eva ; Grewal, Raji P ; Gwinn, Katrina ; Jern, Christina ; Jimenez-Conde, Jordi ; Jood, Katarina ; Katsnelson, Michael ; Kissela, Brett ; Kittner, Steven J ; Kleindorfer, Dawn O ; Labovitz, Daniel L ; Lanfranconi, Silvia ; Lee, Jin-Moo ; Lehm, Manuel ; Lemmens, Robin ; Levi, Chris ; Li, Linxin ; Lindgren, Arne ; Markus, Hugh S ; McArdle, Patrick F ; Melander, Olle ; Norrving, Bo ; Peddareddygari, Leema Reddy ; Pedersén, Annie ; Pera, Joanna ; Rannikmäe, Kristiina ; Rexrode, Kathryn M ; Rhodes, David ; Rich, Stephen S ; Roquer, Jaume ; Rosand, Jonathan ; Rothwell, Peter M ; Rundek, Tatjana ; Sacco, Ralph L ; Schmidt, Reinhold ; Schürks, Markus ; Seiler, Stephan ; Sharma, Pankaj ; Slowik, Agnieszka ; Sudlow, Cathie ; Thijs, Vincent ; Woodfield, Rebecca ; Worrall, Bradford B ; Meschia, James F

Keywords:

Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Peripheral Vascular Disease, Neurosciences & Neurology, Cardiovascular System & Cardiology, classification, pathogenesis, phenotype, CAUSATIVE CLASSIFICATION, RELIABILITY, AGREEMENT, VARIANTS, SYSTEM, RISK, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, National Institute of Neurological Disorders and Stroke (U.S.), Phenotype, Stroke, United States, 1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences, 1109 Neurosciences, Neurology & Neurosurgery, 3202 Clinical sciences, 3209 Neurosciences, 4201 Allied health and rehabilitation science

Abstract:

NINDS (National Institute of Neurological Disorders and Stroke)-SiGN (Stroke Genetics Network) is an international consortium of ischemic stroke studies that aims to generate high-quality phenotype data to identify the genetic basis of pathogenic stroke subtypes. This analysis characterizes the etiopathogenetic basis of ischemic stroke and reliability of stroke classification in the consortium.