Title: HP-1γ Controls High-Affinity Antibody Response to T-Dependent Antigens
Authors: Ha, Ngoc *
Pham, Duc Hung *
Shahsafaei, Aliakbar
Naruse, Chie
Asano, Masahide
Thai, To-Ha # ×
Issue Date: 12-Jun-2014
Publisher: Frontiers Research Foundation
Series Title: Frontiers in Immunology vol:5 pages:271
Article number: 10.3389/fimmu.2014.00271
Abstract: In vitro observations suggest a role for the mouse heterochromatin protein 1γ (HP-1γ) in the immune system. However, it has not been shown if and how HP-1γ contributes to immunity in vivo. Here we show that in mice, HP-1γ positively regulates the germinal center reaction and high-affinity antibody response to thymus (T)-dependent antigens by limiting the size of CD8(+) regulatory T-cell (Treg) compartment without affecting progenitor B- or T-cell-development. Moreover, HP-1γ does not control cell proliferation or class switch recombination. Haploinsufficiency of cbx-3 (gene encoding HP-1γ) is sufficient to expand the CD8(+) Treg population and impair the immune response in mice despite the presence of wild-type HP-1α and HP-1β. This is the first in vivo evidence demonstrating the non-redundant role of HP-1γ in immunity.
ISSN: 1664-3224
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
* (joint) first author
× corresponding author
# (joint) last author

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