Administering 25-hydroxyvitamin D3 in vitamin D-deficient young type 1A diabetic patients reduces reactivity against islet autoantigens

Federico, G; Focosi, D; Marchi, B; Randazzo, E; De Donno, M; Vierucci, F; Bugliani, M; Campi, F; Scatena, F; Saggese, G; Mathieu, Chantal; Marchetti, P

doi:10.1016/j.clnu.2014.01.001

Administering 25-hydroxyvitamin D3 in vitamin D-deficient young type 1A diabetic patients reduces reactivity against islet autoantigens

Author:

Federico, G

Focosi, D ; Marchi, B ; Randazzo, E ; De Donno, M ; Vierucci, F ; Bugliani, M ; Campi, F ; Scatena, F ; Saggese, G ; Mathieu, Chantal ; Marchetti, P

Keywords:

Science & Technology, Life Sciences & Biomedicine, Nutrition & Dietetics, Type 1A diabetes mellitus, Vitamin D, 25-Hydroxyvitamin D, ELISpot, Interferon-gamma, BETA-CELL FUNCTION, INSULIN, ADULTS, RISK, Interferon-γ, Adolescent, Autoantigens, C-Peptide, Calcifediol, Child, Diabetes Mellitus, Type 1, Female, Glutamate Decarboxylase, Humans, Insulin-Secreting Cells, Leukocytes, Mononuclear, Male, Proinsulin, Vitamin D Deficiency, 1111 Nutrition and Dietetics, 3210 Nutrition and dietetics

Abstract:

We investigated whether improving 25-hydroxyvitamin D status in young type 1A diabetic patients reduces reactivity of peripheral blood mononuclear cells against islet autoantigens and associates with beta-cell functional changes.