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Title: Genetic and chemical-molecular approach to study persistence in Pseudomonas aeruginosa to combat chronic infections
Other Titles: Genetische en chemisch-moleculaire benadering voor de studie van persistentie in Pseudomonas aeruginosa ter bestrijding van chronische infecties
Authors: Liebens, Veerle; S0161981
Issue Date: 4-Dec-2014
Abstract: <SPAN lang=EN-US style="LINE-HEIGHT: 150%; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US"><SPAN lang=EN-US style="LINE-HEIGHT: 150%; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US"><w:latentstyles  Pseudomonas aeruginosa is an opportunistic pathogen that will initiate infection upon local or general impairment of the host immune system. As the number of people receiving immunosuppression and invasive treatments rises, P. aeruginosa infections are increasingly prevalent. P. aeruginosa is intrinsically resistant to many antibiotics but is also able to acquire additional resistance mechanisms, giving rise to strains unsusceptible to nearly all available antibiotics. However, even in the absence of detectable resistance, infections are often difficult to treat. A major factor responsible for treatment failure is the presence of persister cells, phenotypic variants of the wild type insensitive to the action of bactericidal agents. Upon withdrawal of the antibiotic, persisters revert to regular cells and regrow into a susceptible population, causing relapse of infection. They prolong the stay of the pathogen in the human body in the presence of antibiotics, leading to an increased probability of developing resistance. Targeting these persisters will greatly improve treatment. <SPAN lang=EN-US style="LINE-HEIGHT: 150%; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US"><SPAN lang=EN-US style="LINE-HEIGHT: 150%; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US"><w:latentstyles  Here, we aim to obtain more insight into the mechanistic basis of persistence of P. aeruginosa by characterizing a newly identified gene with a role in antibiotic tolerance. Secondly, we initiated a new research line in which a top-down approach was used to identify compounds that, in combination with conventional antibiotics, reduce the persister fraction of P. aeruginosa.
Publication status: published
KU Leuven publication type: TH
Appears in Collections:Centre of Microbial and Plant Genetics

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