Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis
Wu, Shaoping Zhang, Yong-Guo Lu, Rong Xia, Yinglin Zhou, David Petrof, Elaine O Claud, Erika C Chen, Di Chang, Eugene B Carmeliet, Geert Sun, Jun # ×
BMJ Publishing Group
Gut vol:64 issue:7 pages:1082-94
Vitamin D and the vitamin D receptor (VDR) appear to be important immunological regulators of inflammatory bowel diseases (IBD). Defective autophagy has also been implicated in IBD, where interestingly, polymorphisms of genes such as ATG16L1 have been associated with increased risk. Although vitamin D, the microbiome and autophagy are all involved in pathogenesis of IBD, it remains unclear whether these processes are related or function independently.