Wong, Michael Sze Ka × Leisegang, Matthias S Kruse, Christoph Vogel, Juri Schürmann, Christoph Dehne, Nathalie Weigert, Andreas Herrmann, Eva Brüne, Bernhard Shah, Ajay M Steinhilber, Dieter Offermanns, Stefan Carmeliet, Geert Badenhoop, Klaus Schröder, Katrin Brandes, Ralf P #
Lippincott Williams & Wilkins
Circulation vol:130 issue:12 pages:976-86
Vitamin D deficiency in humans is frequent and has been associated with inflammation. The role of the active hormone 1,25-dihydroxycholecalciferol (1,25-dihydroxy-vitamin D3; 1,25-VitD3) in the cardiovascular system is controversial. High doses induce vascular calcification; vitamin D3 deficiency, however, has been linked to cardiovascular disease because the hormone has anti-inflammatory properties. We therefore hypothesized that 1,25-VitD3 promotes regeneration after vascular injury.