Title: Discovery of a nanomolar inhibitor of lung adenocarcinoma in vitro
Authors: Shelton, Jadd R ×
Balzarini, Jan
Peterson, Matt A #
Issue Date: Nov-2014
Series Title: Bioorganic & medicinal chemistry letters vol:24 pages:5107-5110
Article number: S0960-894X(14)00888-9
Abstract: Efficient methods for the preparation of 5'-substituted 5'-amino-5'-deoxy-N(6)-ureidoadenosine derivatives are described. Compounds were screened for antiproliferative activity against a panel of murine and human cell lines (L1210, CEM, and HeLa) and/or against the NCI-60. The most potent derivative inhibited the lung adenocarcinoma cell line NCI-H522 at low nanomolar concentrations (GI50=9.7nM).
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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