Title: VP6 genetic diversity, reassortment, intragenic recombination and classification of rotavirus B in American and Japanese pigs
Authors: Marthaler, Douglas ×
Suzuki, Tohru
Rossow, Kurt
Culhane, Marie
Collins, James
Goyal, Sagar
Tsunemitsu, Hiroshi
Ciarlet, Max
Matthijnssens, Jelle #
Issue Date: Aug-2014
Publisher: Elsevier Scientific Pub. Co.
Series Title: Veterinary Microbiology vol:172 issue:3-4 pages:359-366
Article number: 10.1016/j.vetmic.2014.05.015
Abstract: Rotavirus B (RVB) has been identified as a causative agent of diarrhea in rats, humans, cattle, lambs, and swine. Recently, 20 RVB VP7 genotypes were determined based on an 80% nucleotide percent cut-off value. In this study, we sequenced the RVB VP6 gene segment from 80 RVB positive swine samples from the United States and Japan. Phylogenetic analyses, using the 30 available RVB VP6 sequences from GenBank and our 80 novel RVB VP6 sequences, revealed a large genetic diversity of RVB strains, mainly in pigs. For classification purposes, pairwise identity frequency analyses suggested an 81% nucleotide percent cut-off value, resulting in 13 RVB VP6 (I) genotypes. In addition, an intragenic recombinant RVB VP6 segment was identified from Japan. Furthermore, the data indicates frequent reassortment events occurred between the porcine RVB VP7 and VP6 gene segments.
ISSN: 0378-1135
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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