A homeostatic function of CXCR2 signalling in articular cartilage
Sherwood, Joanna × Bertrand, Jessica Nalesso, Giovanna Poulet, Blandine Pitsillides, Andrew Brandolini, Laura Karystinou, Alexandra De Bari, Cosimo Luyten, Frank Pitzalis, Costantino Pap, Thomas Dell'Accio, Francesco #
Annals of the Rheumatic Diseases vol:74 issue:12 pages:2207-2215
ELR+ CXC chemokines are heparin-binding cytokines signalling through the CXCR1 and CXCR2 receptors. ELR+ CXC chemokines have been associated with inflammatory arthritis due to their capacity to attract inflammatory cells. Here, we describe an unsuspected physiological function of these molecules in articular cartilage homeostasis.