Title: Identification and characterization of an anti-pseudomonal dichlorocarbazol derivative displaying anti-biofilm activity
Authors: Liebens, Veerle
Gerits, Evelien
Knapen, Wouter #
Swings, Toon
Beullens, Serge #
Steenackers, Hans
Robijns, Stijn
Lippell, A.
O’Neill, A.
Veber, M.
Fröhlich, M.
Krona, A.
Lövenklev, M. #
Corbau, Romu
Marchand, Arnaud #
Chaltin, Patrick
De Brucker, Katrijn #
Thevissen, Karin
Cammue, Bruno #
Fauvart, Maarten
Verstraeten, Natalie
Michiels, Jan # ×
Issue Date: Oct-2014
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:24 issue:23 pages:5404-5408
Abstract: Pseudomonas aeruginosa strains resistant towards all currently available antibiotics are increasingly encountered, raising the need for new anti-pseudomonal drugs. We therefore conducted a medium-throughput screen of a small-molecule collection resulting in the identification of N-alkylated 3, 6-dihalogenocarbazol 1-(sec-butylamino)-3-(3,6-dichloro-9H-carbazol-9-yl)propan-2-ol (MIC = 18.5 µg mL-1). This compound, compound 1, is bacteriostatic towards a broad spectrum of Gram-positive and Gram-negative pathogens, including P. aeruginosa. Importantly, 1 also eradicates mature biofilms of P. aeruginosa. 1 displays no cytotoxicity against various human cell types, pointing to its potential for further development as a novel antibacterial drug.  
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre of Microbial and Plant Genetics
Intellectual Property
× corresponding author
# (joint) last author

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