ITEM METADATA RECORD
Title: Secreted frizzled related proteins inhibit fibrosis in vitro but appear redundant in vivo
Authors: De Langhe, Ellen ×
Aznar Lopez, Carolina
De Vooght, Vanessa
Vanoirbeek, Jeroen
Luyten, Frank
Lories, Rik #
Issue Date: Oct-2014
Publisher: BioMed Central Ltd.
Series Title: Fibrogenesis & Tissue Repair vol:7
Article number: 14
Abstract: The pathogenesis of pulmonary fibrosis remains poorly understood. The Wnt signaling pathway regulates fibrogenesis in different organs. Here, we studied the role of two extracellular Wnt antagonists, secreted frizzled-related protein-1 (SFRP1) and frizzled-related protein (FRZB) on lung fibrosis in vitro and in vivo. For this purpose, we used an alveolar epithelial cell line and a lung fibroblast cell line, and the bleomycin-induced lung fibrosis model, respectively.
ISSN: 1755-1536
VABB publication type: VABB-1
Publication status: published
KU Leuven publication type: DI
Appears in Collections:Skeletal Biology and Engineering Research Center (+)
Environment and Health - miscellaneous
× corresponding author
# (joint) last author

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