Title: High-dosage tamoxifen as neoadjuvant treatment in minimally invasive surgery for Dupuytren disease in patients with a strong predisposition toward fibrosis: a randomized controlled trial
Authors: Degreef, Ilse ×
Tejpar, Sabine
Sciot, Raf
De Smet, Luc #
Issue Date: Apr-2014
Publisher: Journal of Bone and Joint Surgery
Series Title: Journal of Bone and Joint Surgery. American Volume vol:96 issue:8 pages:655-62
Article number: 10.2106/JBJS.L.01623
Abstract: Tamoxifen, a synthetic nonsteroidal anti-estrogen known to modulate the production of transforming growth factor-beta (TGF-β), has demonstrated effectiveness on fibroblast activity in vitro and in vivo. The main purpose of this study was to investigate the effect of tamoxifen on the outcome of surgery for Dupuytren contractures in patients with a strong predisposition toward fibrosis.
ISSN: 0021-9355
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Organ Systems (+)
Molecular Digestive Oncology (+)
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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