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Title: Synthesis and anti-HIV activity of N'-nicotinoyl--3-(4'-hydroxy-3'-methylphenyl)-5-[substituted phenyl]-2-pyrazolines
Authors: Ali, Mohamed A ×
Yar, Mohammad Shahar
Siddiqui, Anees A
Sriram, Dharmarajan
Yogeeswari, Perumal
De Clercq, Erik #
Issue Date: 2007
Series Title: Acta poloniae pharmaceutica vol:64 issue:5 pages:423-8
Abstract: A series of N'-nicotinoyl-3-(4'-hydroxy-3'-methylphenyl)-5-(substituted phenyl)-2-pyrazolines were synthesized by the reaction between isoniazid (INH) and chalcones and were tested for their in vitro anti-HIV activity. Among them, compound (c) showed a promising anti-HIV activity in vitro against used strains (IIIB, ROD), with IC50 of both IIIB 5.7 microM and ROD 7.0 microM.
ISSN: 0001-6837
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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