Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Cell Biology, CYCLIC ADP-RIBOSE, CHANNEL RYANODINE RECEPTOR, MITOCHONDRIAL CA2+ UPTAKE, CARDIAC-HYPERTROPHY, INTRACELLULAR CA2+, CADP-RIBOSE, CALCINEURIN CONTROLS, RELEASE CHANNEL, CYTOSOLIC CA2+, OVEREXPRESSING CALSEQUESTRIN, Animals, Calcium, Calcium Channels, Calcium Signaling, Homeostasis, Humans, Models, Biological, Second Messenger Systems, 06 Biological Sciences, 11 Medical and Health Sciences, Developmental Biology, 31 Biological sciences, 32 Biomedical and clinical sciences, 42 Health sciences

Abstract:

Ca2+ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. An extensive Ca2+-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics. Rapid highly localized Ca2+ spikes regulate fast responses, whereas slower responses are controlled by repetitive global Ca2+ transients or intracellular Ca2+ waves. Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.