Title: Epidemiology and outcome of invasive pneumococcal disease among adults in Belgium, 2009-2011
Authors: Verhaegen, Jan ×
Flamaing, Johan
De Backer, W
Delaere, B
Van Herck, K
Surmont, F
Van Laethem, Y
Van Damme, P
Peetermans, Willy #
Issue Date: 2014
Series Title: Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin vol:19 issue:31 pages:14-22
Article number: 20869
Abstract: This epidemiological study examined morbidity and case fatality of invasive pneumococcal disease (IPD) in adults in Belgium as well as distribution and antibiotic susceptibility of Streptococcus pneumoniae serotypes.Adults hospitalised with microbiologically proven IPD were prospectively enrolled. The study started in 2009 with patients aged ≥50 years, whereas in 2010 and 2011, patients aged ≥18 years were included. The clinical presentation, patient profile, treatment, outcome, and mortality were recorded during hospitalisation.Outcome was also assessed one month afterdischarge. Of the 1,875 patients with IPD identified, 1,332 were included in the analysis. Bacteraemic pneumonia, affecting 1,049 of the patients, was the most frequent IPD type (79%), and chronic obstructive pulmonary disease and cancer were the main comorbidities.One-third of patients required admission to intensive care unit. A total of 208 (16%) patients died during hospitalisation and an additional 21 (2%) within one month after discharge. Case fatality rates of ≥20%were observed in patients with chronic heart failure, hepatic disease, and renal insufficiency. Serotypes 7F, 1, 19A, and 3 were the most prevalent and together accounted for 47% (569/1,214) of all IPD cases and 42% (80/189) of mortality. Of the patient isolates, 21% (255/1,204) were resistant to erythromycin and 22% (264/1,204) to tetracycline. Penicillin non-susceptibility was mostly found in serotype 19A isolates. These baseline data are essential when assessing the impact of pneumococcal conjugate vaccination in adults in the future.
ISSN: 1560-7917
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Clinical Infectious and Inflammatory Disorders
Gerontology and Geriatrics
Department of Health and Technology - UC Leuven
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

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