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Title: Conotoxins targeting nicotinic acetylcholine receptors: an overview
Authors: Lebbe, Eline
Peigneur, Steve
Wijesekara, Isuru
Tytgat, Jan # ×
Issue Date: 22-May-2014
Publisher: Molecular Diversity Preservation International
Series Title: Marine Drugs vol:12 issue:5 pages:2970-3004
Abstract: Marine snails of the genus Conus are a large family of predatory gastropods with an unparalleled molecular diversity of pharmacologically active compounds in their venom. Cone snail venom comprises of a rich and diverse cocktail of peptide toxins which act on a wide variety of ion channels such as voltage-gated sodium- (NaV), potassium- (KV), and calcium- (CaV) channels as well as nicotinic acetylcholine receptors (nAChRs) which are classified as ligand-gated ion channels. The mode of action of several conotoxins has been the subject of investigation, while for many others this remains unknown. This review aims to give an overview of the knowledge we have today on the molecular pharmacology of conotoxins specifically interacting with nAChRs along with the structure-function relationship data
ISSN: 1660-3397
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Toxicology and Pharmacology
× corresponding author
# (joint) last author

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