Title: S100A4 is upregulated in proliferative diabetic retinopathy and correlates with markers of angiogenesis and fibrogenesis
Authors: Abu El-Asrar, Ahmed M ×
Nawaz, Mohd Imtiaz
De Hertogh, Gert
Alam, Kaiser
Siddiquei, Mohammad Mairaj
Van den Eynde, Kathleen
Mousa, Ahmed
Mohammad, Ghulam
Geboes, Karel
Opdenakker, Ghislain #
Issue Date: Sep-2014
Series Title: Molecular vision vol:20 pages:1209-1224
Abstract: The calcium-binding protein S100A4 is implicated in cancer cell invasion and metastasis, the stimulation of angiogenesis, the progression of fibrosis, and inflammatory disorders. We investigated the expression of S100A4 and correlated it with clinical disease activity as well as with the levels of osteopontin (OPN), soluble syndecan-1, and vascular endothelial growth factor (VEGF) in proliferative diabetic retinopathy (PDR). To reinforce the findings at the functional level, we examined the expressions of S100A4 and OPN in the retinas of diabetic rats and in human retinal microvascular endothelial cells (HRMECs) following exposure to VEGF and the proinflammatory cytokine tumor necrosis factor-α (TNF-α).
ISSN: 1090-0535
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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