Title: Membranes based on poly(gamma-methyl-L-glutamate): synthesis, characterization and use in chiral separations
Authors: Thoelen, C ×
De Bruyn, Mario
Theunissen, Elisabeth
Kondo, Y
Vankelecom, Ivo
Grobet, Pierre
Yoshikawa, M
Jacobs, Pierre #
Issue Date: 2001
Publisher: Elsevier science bv
Series Title: Journal of membrane science vol:186 issue:2 pages:153-163
Abstract: A facile 'one-pot' synthesis for poly(gamma -methyl-L-glutamate) (PMLG) membranes is reported. Despite having an alpha -helical secondary structure, as demonstrated via IR, these membranes did not show enantioselective behavior in pressure driven permeation of Trp. Therefore, the transesterification of PMLG with Igepal and Brij(R) 30 is introduced in a next step and the resulting polymers are characterized by means of IR and NMR. Supported membranes made from these materials show permselectivity towards D-Trp under a pressure gradient, but the enantiomeric excess of the permeate phase declines as a function of time. In order to realize a constant enantioselectivity, electrodialysis is demonstrated to be a suitable membrane process. Moreover, the obtained permeation rates of Ac-Trp are among the best ever reported for solid enantioselective membranes and approximate those realized with liquid membranes. (C) 2001 Elsevier Science B.V. All rights reserved.
ISSN: 0376-7388
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre for Surface Chemistry and Catalysis
× corresponding author
# (joint) last author

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