Title: Sedation using propofol induces similar diaphragm dysfunction and atrophy during spontaneous breathing and mechanical ventilation in rats
Authors: Bruells, Christian S ×
Maes, Karen
Rossaint, Rolf
Thomas, Debby
Cielen, Nele
Bergs, Ingmar
Bleilevens, Christian
Weis, Joachim
Gayan-Ramirez, Ghislaine #
Issue Date: Mar-2014
Publisher: American Society of Anesthesiologists
Series Title: Anesthesiology vol:120 issue:3 pages:665-672
Article number: 10.1097/ALN.0000000000000125
Abstract: Mechanical ventilation is crucial for patients with respiratory failure. The mechanical takeover of diaphragm function leads to diaphragm dysfunction and atrophy (ventilator-induced diaphragmatic dysfunction), with an increase in oxidative stress as a major contributor. In most patients, a sedative regimen has to be initiated to allow tube tolerance and ventilator synchrony. Clinical data imply a correlation between cumulative propofol dosage and diaphragm dysfunction, whereas laboratory investigations have revealed that propofol has some antioxidant properties. The authors hypothesized that propofol reduces markers of oxidative stress, atrophy, and contractile dysfunction in the diaphragm.
ISSN: 0003-3022
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pneumology
Gynaecological Oncology
× corresponding author
# (joint) last author

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