Title: A multivariate multilevel Gaussian model with a mixed effects structure in the mean and covariance part
Authors: Li, Baoyue ×
Bruyneel, Luk
Lesaffre, Emmanuel #
Issue Date: May-2014
Publisher: John Wiley & Sons
Series Title: Statistics in Medicine vol:33 issue:11 pages:1877-1899
Article number: 10.1002/sim.6062
Abstract: A traditional Gaussian hierarchical model assumes a nested multilevel structure for the mean and a constant variance at each level. We propose a Bayesian multivariate multilevel factor model that assumes a multilevel structure for both the mean and the covariance matrix. That is, in addition to a multilevel structure for the mean we also assume that the covariance matrix depends on covariates and random effects. This allows to explore whether the covariance structure depends on the values of the higher levels and as such models heterogeneity in the variances and correlation structure of the multivariate outcome across the higher level values. The approach is applied to the three-dimensional vector of burnout measurements collected on nurses in a large European study to answer the research question whether the covariance matrix of the outcomes depends on recorded system-level features in the organization of nursing care, but also on not-recorded factors that vary with countries, hospitals, and nursing units. Simulations illustrate the performance of our modeling approach. Copyright © 2013 John Wiley & Sons, Ltd.
ISSN: 0277-6715
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Centre for Nursing and Midwifery
Nursing and Health Care Management Teaching Methodology and Practicals
Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat)
× corresponding author
# (joint) last author

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