Title: Anomalous Dynamics of DNA Hairpin Folding
Authors: Frederickx, Roald ×
in't Veld, Thomas
Carlon, Enrico #
Issue Date: 14-May-2014
Series Title: PHYSICAL REVIEW LETTERS vol:112 issue:19 pages:198102-198107
Abstract: By means of computer simulations of a coarse-grained DNA model we show that the DNA hairpin zippering dynamics is anomalous; i.e., the characteristic time scales nonlinearly with , the hairpin length, with . This is in sharp contrast to the prediction of the zipper model for which . We show that the anomalous dynamics originates from an increase in the friction during zippering due to the tension built in the closing strands. From a simple polymer model we get with being the Flory exponent, a result which is in agreement with the simulations. We discuss transition path times data where such effects should be detected.
ISSN: 0031-9007
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Theoretical Physics Section
Gene Expression Unit
Informatics Section
× corresponding author
# (joint) last author

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