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Title: Comparison of effects of anti-angiogenic agents in the zebrafish efficacy-toxicity model for translational anti-angiogenic drug discovery
Authors: Chimote, Geetanjali ×
Sreenivasan, Jayasree
Pawar, Nilambari
Subramanian, Jyothi
Sivaramakrishnan, Hariharan
Sharma, Somesh #
Issue Date: Aug-2014
Series Title: Drug design, development and therapy vol:8 pages:1107-23
Article number: 10.2147/DDDT.S55621
Abstract: Anti-angiogenic therapy in certain cancers has been associated with improved control of tumor growth and metastasis. Development of anti-angiogenic agents has, however, been saddled with higher attrition rate due to suboptimal efficacy, narrow therapeutic windows, or development of organ-specific toxicities. The aim of this study was to evaluate the translational ability of the zebrafish efficacy-toxicity model to stratify anti-angiogenic agents based on efficacy, therapeutic windows, and off-target effects to streamline the compound selection process in anti-angiogenic discovery.
URI: 
ISSN: 1177-8881
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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