Title: A mutation in the hepatitis E virus RNA polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients
Authors: Debing, Yannick *
Gisa, Anett *
Dallmeier, Kai
Pischke, Sven
Bremer, Birgit
Manns, Michael
Wedemeyer, Heiner
Suneetha, Pothakamuri Venkata
Neyts, Johan # ×
Issue Date: Nov-2014
Publisher: W.B. Saunders
Series Title: Gastroenterology vol:147 pages:1008-1011
Article number: pii: S0016-5085(14)01079-8.
Abstract: We analyzed blood samples collected from 15 patients with chronic hepatitis E who were recipients of solid-organ transplants. All patients cleared the hepatitis E virus (HEV) except for 2 (nonresponders); 1 patient died. A G1634R mutation in viral polymerase was detected in the HEV RNA of the non-responders; this mutation did not provide the virus with resistance to ribavirin in vitro. However, the mutant form of a subgenomic replicon of genotype 3 HEV replicated more efficiently in vitro than HEV without this mutation, and the same was true for infectious virus, including in competition assays. Similar results were obtained for genotype 1 HEV. The G1634R mutation therefore appears to increase the replicative capacity of HEV in the human liver and hence reduce the efficacy of ribavirin.
ISSN: 0016-5085
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
* (joint) first author
× corresponding author
# (joint) last author

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