Title: CCR5 as a Treatment Target in Pulmonary Arterial Hypertension
Authors: Amsellem, Valérie ×
Lipskaia, Larissa
Abid, Shariq
Poupel, Lucie
Houssaini, Amal
Quarck, Rozenn
Marcos, Elisabeth
Mouraret, Nathalie
Parpaleix, Aurélien
Bobe, Régis
Gary-Bobo, Guillaume
Saker, Mirna
Dubois-Randé, Jean-Luc
Gladwin, Mark T
Norris, Karen A
Delcroix, Marion
Combadière, Christophe
Adnot, Serge #
Issue Date: Sep-2014
Series Title: Circulation vol:130 issue:11 pages:880-91
Article number: 10.1161/CIRCULATIONAHA.114.010757
Abstract: Pulmonary arterial hypertension (PH), whether idiopathic or related to underlying diseases such as HIV infection, results from complex vessel remodeling involving both pulmonary artery smooth muscle cell (PA-SMC) proliferation and inflammation. CCR5, a coreceptor for cellular HIV-1 entry expressed on macrophages and vascular cells, may be involved in the pathogenesis of PH. Maraviroc is a new CCR5 antagonist designed to block HIV entry.
ISSN: 0009-7322
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pneumology
× corresponding author
# (joint) last author

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