Title: Survival in Patients with High-Risk Prostate Cancer Is Predicted by miR-221, Which Regulates Proliferation, Apoptosis, and Invasion of Prostate Cancer Cells by Inhibiting IRF2 and SOCS3
Authors: Kneitz, Burkhard ×
Krebs, Markus
Kalogirou, Charis
Schubert, Maria
Joniau, Steven
Van Poppel, Hendrik
Lerut, Evelyne
Kneitz, Susanne
Scholz, Claus Jürgen
Ströbel, Philipp
Gessler, Manfred
Riedmiller, Hubertus
Spahn, Martin #
Issue Date: May-2014
Publisher: Waverly Press
Series Title: Cancer Research vol:74 issue:9 pages:2591-2603
Abstract: A lack of reliably informative biomarkers to distinguish indolent and lethal prostate cancer is one reason this disease is overtreated. miR-221 has been suggested as a biomarker in high-risk prostate cancer, but there is insufficient evidence of its potential utility. Here we report that miR-221 is an independent predictor for cancer-related death, extending and validating earlier findings. By mechanistic investigations we showed that miR-221 regulates cell growth, invasiveness, and apoptosis in prostate cancer at least partially via STAT1/STAT3-mediated activation of the JAK/STAT signaling pathway. miR-221 directly inhibits the expression of SOCS3 and IRF2, two oncogenes that negatively regulate this signaling pathway. miR-221 expression sensitized prostate cancer cells for IFN-γ-mediated growth inhibition. Our findings suggest that miR-221 offers a novel prognostic biomarker and therapeutic target in high-risk prostate cancer. Cancer Res; 74(9); 2591-603. ©2014 AACR.
ISSN: 0008-5472
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Organ Systems (+)
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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