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British Journal of Cancer

Publication date: 2014-02-01
Volume: 110 Pages: 1088 - 100
Publisher: Harcourt Publishers

Author:

Agarwal, D
Pineda, S ; Michailidou, K ; Herranz, J ; Pita, G ; Moreno, LT ; Alonso, MR ; Dennis, J ; Wang, Q ; Bolla, MK ; Meyer, KB ; Menéndez-Rodríguez, P ; Hardisson, D ; Mendiola, M ; González-Neira, A ; Lindblom, A ; Margolin, S ; Swerdlow, A ; Ashworth, A ; Orr, N ; Jones, M ; Matsuo, K ; Ito, H ; Iwata, H ; Kondo, N ; kConFab Investigators, ; Australian Ovarian Cancer Study Group, ; Hartman, M ; Hui, M ; Lim, WY ; Iau, PT-C ; Sawyer, E ; Tomlinson, I ; Kerin, M ; Miller, N ; Kang, Diye ; Choi, J-Y ; Park, SK ; Noh, D-Y ; Hopper, JL ; Schmidt, DF ; Makalic, E ; Southey, MC ; Teo, SH ; Yip, CH ; Sivanandan, K ; Tay, W-T ; Brauch, H ; Brüning, T ; Hamann, U ; GENICA Network, ; Dunning, AM ; Shah, M ; Andrulis, IL ; Knight, JA ; Glendon, G ; Tchatchou, S ; Schmidt, MK ; Broeks, A ; Rosenberg, EH ; van't Veer, LJ ; Fasching, PA ; Renner, SP ; Ekici, AB ; Beckmann, MW ; Shen, C-Y ; Hsiung, C-N ; Yu, J-C ; Hou, M-F ; Blot, W ; Cai, Q ; Wu, AH ; Tseng, C-C ; Van Den Berg, D ; Stram, DO ; Cox, Ann ; Brock, IW ; Reed, MWR ; Muir, K ; Lophatananon, A ; Stewart-Brown, S ; Siriwanarangsan, P ; Zheng, W ; Deming-Halverson, S ; Shrubsole, MJ ; Long, J ; Shu, X-O ; Lu, W ; Gao, Y-T ; Zhang, Biao ; Radice, P ; Peterlongo, P ; Manoukian, S ; Mariette, F ; Sangrajrang, S ; McKay, J ; Couch, FJ ; Toland, AE ; TNBCC, ; Yannoukakos, D ; Fletcher, O ; Johnson, N ; dos Santos Silva, I ; Peto, J ; Marme, F ; Burwinkel, B ; Guénel, P ; Truong, T ; Sanchez, M ; Mulot, C ; Bojesen, SE ; Nordestgaard, BG ; Flyer, H ; Brenner, H ; Dieffenbach, AK ; Arndt, V ; Stegmaier, C ; Mannermaa, A ; Kataja, V ; Kosma, V-M ; Hartikainen, JM ; Lambrechts, Diether ; Yesilyurt, BT ; Floris, Beppe ; Leunen, Karin ; Chang-Claude, J ; Rudolph, A ; Seibold, P ; Flesch-Janys, D ; Wang, X ; Olson, JE ; Vachon, C ; Purrington, K ; Giles, GG ; Severi, G ; Baglietto, L ; Haiman, CA ; Henderson, BE ; Schumacher, F ; Marchand, L Le ; Simard, J ; Dumont, M ; Goldberg, MS ; Labréche, F ; Winqvist, R ; Pylkäs, K ; Jukkola-Vuorinen, A ; Grip, M ; Devilee, P ; Tollenaar, RAEM ; Seynaeve, C ; García-Closas, M ; Chanock, SJ ; Lissowska, J ; Figueroa, JD ; Czene, K ; Eriksson, M ; Humphreys, K ; Darabi, H ; Hooning, MJ ; Kriege, M ; Collée, JM ; Tilanus-Linthorst, M ; Li, J ; Jakubowska, A ; Lubinski, J ; Jaworska-Bieniek, K ; Durda, K ; Nevanlinna, H ; Muranen, TA ; Aittomäki, K ; Blomqvist, C ; Bogdanova, N ; Dörk, T ; Hall, P ; Chenevix-Trench, G ; Easton, DF ; Pharroah, PDP ; Arias-Perez, JI ; Zamora, P ; Benítez, J ; Milne, RL

Keywords:

Breast Neoplasms, Case-Control Studies, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Humans, Polymorphism, Single Nucleotide, Receptor, Fibroblast Growth Factor, Type 1, Receptor, Fibroblast Growth Factor, Type 2, Receptor, Fibroblast Growth Factor, Type 3, Receptor, Fibroblast Growth Factor, Type 4, Receptor, Fibroblast Growth Factor, Type 5, Science & Technology, Life Sciences & Biomedicine, Oncology, breast cancer, SNP, FGF receptors, susceptibility, disease subtypes, GENOME-WIDE ASSOCIATION, CONFER SUSCEPTIBILITY, COMMON VARIANTS, IDENTIFIES 2, RISK, LOCUS, BRCA1, MUTATIONS, ALLELES, kConFab Investigators, Australian Ovarian Cancer Study Group, GENICA Network, TNBCC, 1112 Oncology and Carcinogenesis, 1117 Public Health and Health Services, Oncology & Carcinogenesis, 3211 Oncology and carcinogenesis

Abstract:

Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.