Title: Deficient motor timing in children with neurofibromatosis type 1
Authors: Debrabant, Julie ×
Plasschaert, Ellen
Caeyenberghs, Karen
Vingerhoets, Guy
Legius, Eric
Janssens, Sandra
Van Waelvelde, Hilde #
Issue Date: Aug-2014
Series Title: Research in developmental disabilities vol:35 issue:11 pages:3131-3138
Article number: S0891-4222(14)00338-2
Abstract: Neurofibromatosis type 1 (NF1) is one of the most common single-gene disorders affecting fine and visual-motor skills. This case-control study investigated motor timing as a possible related performance deficit in children with NF1. A visual-motor reaction time (VRT) test was administered in 20 NF1 children (mean age 9 years 7 months) and 20 age- and gender-matched typically developing (TD) children. Copying and tracing performance were evaluated using the Beery-Buktenica Developmental Test of Visual-Motor Integration (Beery VMI). Children with NF1 responded with an increased reaction time (RT) to temporally predictive stimuli compared to TD children, whereas RT at unpredictive stimuli did not differ between groups. Motor timing indexed by the RT decrease at predictive stimuli significantly associated with the Beery VMI copy and tracing outcomes. Deficient motor timing as an actual symptom may add to further research on the pathogenesis of NF1-associated motor impairment and the development of more effective treatment.
ISSN: 0891-4222
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory for Neurofibromatosis Research
× corresponding author
# (joint) last author

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