Title: Semisynthetic teicoplanin derivatives as new influenza virus binding inhibitors: synthesis and antiviral studies
Authors: Bereczki, Ilona ×
Kicsák, Máté
Dobray, Laura
Borbás, Anikó
Batta, Gyula
Kéki, Sándor
Nikodém, Éva Nemes
Ostorházi, Eszter
Rozgonyi, Ferenc
Vanderlinden, Evelien
Naesens, Lieve
Herczegh, Pál #
Issue Date: Aug-2014
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:24 issue:15 pages:3251-3254
Article number: 10.1016/j.bmcl.2014.06.018
Abstract: In order to obtain new, cluster-forming antibiotic compounds, teicoplanin pseudoaglycone derivatives containing two lipophilic n-octyl chains have been synthesized. The compounds proved to be poor antibacterials, but, surprisingly, they exhibited potent anti-influenza virus activity against influenza A strains. This antiviral action was related to inhibition of the binding interaction between the virus and the host cell. Related analogs bearing methyl substituents in lieu of the octyl chains, displayed no anti-influenza virus activity. Hence, an interaction between the active, dually n-octylated compounds and the lipid bilayer of the host cell can be postulated, to explain the observed inhibition of influenza virus attachment.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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