Title: Azapropellanes with anti-influenza a virus activity
Authors: Torres, Eva ×
Leiva, Rosana
Gazzarrini, Sabrina
Rey-Carrizo, Matías
Frigolé-Vivas, Marta
Moroni, Anna
Naesens, Lieve
Vázquez, Santiago #
Issue Date: Jul-2014
Series Title: ACS medicinal chemistry letters vol:5 issue:7 pages:831-6
Article number: 10.1021/ml500108s
Abstract: The synthesis of several [4,4,3], [4,3,3], and [3,3,3]azapropellanes is reported. Several of the novel amines displayed low-micromolar activities against an amantadine-resistant H1N1 strain, but they did not show activity against an amantadine-sensitive H3N2 strain. None of the tested compounds inhibit the influenza A/M2 proton channel function. Most of the compounds did not show cytotoxicity for MDCK cells.
ISSN: 1948-5875
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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