Title: Genes with internal repeats require the THO complex for transcription
Authors: Voynov, V. ×
Verstrepen, Kevin
Jansen, An
Runner, V. M.
Buratowski, S.
Fink, G. R. #
Issue Date: 26-Aug-2006
Series Title: Proceedings of the National Academy of Sciences of the United States of America vol:103 issue:39 pages:14423-14428
Abstract: The evolutionarily conserved multisubunit THO complex, which is recruited to actively transcribed genes, is required for the efficient expression of FLO11 and other yeast genes that have long internal tandem repeats. FLO11 transcription elongation in Tho- mutants is hindered in the region of the tandem repeats, resulting in a loss of function. Moreover, the repeats become genetically unstable in Tho- mutants. A FLO11 gene without the tandem repeats is transcribed equally well in Tho+ or Tho- strains. The Tho- defect in transcription is suppressed by overexpression of topoisomerase I, suggesting that the THO complex functions to rectify aberrant structures that arise during transcription.
ISSN: 0027-8424
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre of Microbial and Plant Genetics
× corresponding author
# (joint) last author

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