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Title: Patch testing with methylchloroisothiazolione / methylisothiazolinone 200 ppm aq. detects significantly more contact allergy than 100 ppm. A multicentre study within the European Environmental and Contact Dermatitis Research Group
Authors: Bruze, Magnus
Isaksson, Marléne ×
Gruvberger, Birgitta
Andersen, Klaus E.
Gonçalo, Margarida
Goossens, An
Johansen, Jeanne D.
Maibach, Howard I.
Rustemeyer, Thomas
Le Coz, Christophe-J.
White, Ian R. #
Issue Date: 9-Apr-2014
Publisher: Munksgaard
Series Title: Contact Dermatitis vol:71 issue:1 pages:31-34
Abstract: BACKGROUND:
Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are the active ingredients in commonly used preservative systems (e.g. Kathon CG(®)). MCI/MI is present in the European baseline patch test series at 100 ppm aq. Since 1986, 200 ppm (dose 0.006 mg/cm(2)) has been used in Sweden without causing skin irritation. Centres in Spain, the United Kingdom and Ireland have also used 200 ppm in their baseline series.
OBJECTIVES:
To find the optimal patch test concentration for MCI/MI.
MATERIALS AND METHODS:
MCI/MI 100 ppm aq. and MCI/MI 200 ppm aq. were simultaneously patch tested in 3300 consecutively tested dermatitis patients at eight European patch test clinics and one US patch test clinic. With the Finn Chambers(®) technique (diameter 8 mm), 15 µl was micropipetted on to the filter paper in the chamber. The corresponding volume for Van der Bend(®) chambers was 20 µl, and that for IQ Chambers(®) was 25 µl.
RESULTS:
Contact allergy to MCI/MI at 100 and 200 ppm was found in 1.2% and 2.1% of patients, respectively (p < 0.001).
CONCLUSIONS:
MCI/MI 200 ppm aq. (dose 0.006 mg/cm(2) ) diagnoses significantly more contact allergy than the presently used concentration of 100 ppm (dose 0.003 mg/cm(2)), without resulting in more adverse reactions. MCI/MI at 200 ppm should therefore be considered for inclusion in the European baseline test series.
ISSN: 0105-1873
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Dermatology
Laboratory of Dermatoimmunology (+)
× corresponding author
# (joint) last author

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