Title: The dramatic increase in the rate of methylisothiazolinone contact allergy in Belgium: a multicentre study
Authors: Aerts, Olivier ×
Baeck, Marie
Constandt, Lieve
Dezfoulian, Bita
Jacobs, Marie-Claude
Kerre, Stefan
Lapeere, Hilde
Pierret, Lauranne
Wouters, Kristien
Goossens, An #
Issue Date: 12-May-2014
Publisher: Munksgaard
Series Title: Contact Dermatitis vol:71 issue:1 pages:41-48
The rate of contact allergy and allergic contact dermatitis caused by methylisothiazolinone (MI) is dramatically increasing throughout Europe.
To report on methylchloroisothiazolinone (MCI)/MI and MI allergy in Belgium.
Between January 2010 and December 2012, the medical charts of 6599 patients of the Belgian Contact and Environmental Dermatitis Group were retrospectively reviewed for MCI/MI and MI sensitization by use of a standardized questionnaire. Available data on sensitization in 2081 patients tested in 2013 were also included.
In 2012, the sensitization rate for MCI/MI had increased to 4.5% and that for MI to 6.0%; the latter showed a further increase to 7.2% in 2013. The people mainly affected were women with a median age of 49 years with hand and/or facial dermatitis, most often resulting from the use of cosmetics. Simultaneous reactions to octylisothiazolinone were observed.
A dramatic increase in the rate of contact allergy caused by MI in cosmetics is occurring in Belgium. Notwithstanding the recent recommendation to discontinue the use of MI in leave-on cosmetics, safer use concentrations should also be determined for rinse-off products. Close monitoring of MI sensitization in the near future will be necessary, and the highest test concentrations reported for MI and MCI/MI should be included in the baseline series.
ISSN: 0105-1873
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Dermatology
Medicine Teaching Programs
Laboratory of Dermatoimmunology (+)
× corresponding author
# (joint) last author

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