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Title: Blau Syndrome, the prototypic auto-inflammatory granulomatous disease
Authors: Wouters, Carine ×
Maes, Anne
Foley, Kevin P
Bertin, John
Rose, Carlos D #
Issue Date: 2014
Series Title: Pediatric rheumatology online journal vol:12 issue:33 pages:1-9
Abstract: Blau syndrome is a monogenic disease resulting from mutations in the pattern recognition receptor NOD2, and is phenotypically characterized by the triad of granulomatous polyarthritis, dermatitis and uveitis. This paper reviews briefly the classical clinical features of the disease, as well as more recently described extra-triad symptoms. From an ongoing prospective multicenter study, we provide new data on the natural history of Blau syndrome, focusing on functional status and visual outcome. We also present an update of the range of different NOD2 mutations found in Blau syndrome as well as recent data on morphologic and immunohistochemical characteristics of the Blau granuloma. Finally, emerging insights into pathogenic mechanisms including activation of NOD2 signal transduction, and potential biomarkers of disease activity are discussed.
URI: 
ISSN: 1546-0096
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Pediatric Immunology
× corresponding author
# (joint) last author

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