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Title: Characterization and assessment of the sensitivity and resistance of a newly established human gastrointestinal stromal tumour xenograft model to treatment with tyrosine kinase inhibitors
Authors: Van Looy, Thomas Gebreyohannes, Yemarshet Kelemework Wozniak, Agnieszka Cornillie, Jasmien Wellens, Jasmien Li, Haifu Vanleeuw, Ulla Floris, Beppe Debiec-Rychter, Maria Sciot, Raf Schöffski, Patrick # ×
Issue Date: 2014
Series Title: Clinical sarcoma research vol:4 pages:10
Article number: 10.1186/2045-3329-4-10
Abstract: Acquired resistance to tyrosine kinase inhibitors (TKIs) in gastrointestinal stromal tumours (GISTs) is most commonly caused by secondary KIT or PDGFRA mutations. In this study we characterize a newly established GIST xenograft model, UZLX-GIST9, and evaluate the in vivo response of the model to standard TKIs (imatinib, sunitinib, and regorafenib).
Publication status: published
KU Leuven publication type: IT
Appears in Collections: Department of Human Genetics - miscellaneous Laboratory of Experimental Oncology Translational Cell & Tissue Research Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author
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