Title: Characterization of Newly Isolated Lytic Bacteriophages Active against Acinetobacter baumannii
Authors: Merabishvili, Maia
Vandenheuvel, Dieter
Kropinski, Andrew M
Mast, Jan
De Vos, Daniel
Verbeken, Gilbert
Noben, Jean-Paul
Lavigne, Rob
Vaneechoutte, Mario
Pirnay, Jean-Paul # ×
Issue Date: 2014
Publisher: Public Library of Sciene
Series Title: PloS one vol:9 issue:8
Article number: e104853
Abstract: Based on genotyping and host range, two newly isolated lytic bacteriophages, myovirus vB_AbaM_Acibel004 and podovirus vB_AbaP_Acibel007, active against Acinetobacter baumannii clinical strains, were selected from a new phage library for further characterization. The complete genomes of the two phages were analyzed. Both phages are characterized by broad host range and essential features of potential therapeutic phages, such as short latent period (27 and 21 min, respectively), high burst size (125 and 145, respectively), stability of activity in liquid culture and low frequency of occurrence of phage-resistant mutant bacterial cells. Genomic analysis showed that while Acibel004 represents a novel bacteriophage with resemblance to some unclassified Pseudomonas aeruginosa phages, Acibel007 belongs to the well-characterized genus of the Phikmvlikevirus. The newly isolated phages can serve as potential candidates for phage cocktails to control A. baumannii infections.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Gene Technology (-)
Clinical Pharmacology and Pharmacotherapy
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Merabishvilietal_PLosOne.pdf Published 1703KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science