Title: Enantioselective Assembly of a Ruthenium(II) Polypyridyl Complex into a Double Helix
Authors: Van Hecke, Kristof ×
Cardinaels, Thomas
Nockemann, Peter
Jacobs, Jeroen
Vanpraet, Louis
Parac-Vogt, Tatjana.
Van Deun, Rik
Binnemans, Koen
Van Meervelt, Luc #
Issue Date: 2014
Publisher: Wiley-VCH
Series Title: Angewandte Chemie - International Edition vol:53 issue:34 pages:8959-8962
Abstract: Evolution can increase the complexity of matter by self-organization into helical architectures, the best example being the DNA double helix. One common aspect, apparently shared by most of these architectures, is the presence of covalent bonds within the helix backbone. Here, we report the unprecedented crystal structures of a metal complex that self-organizes into a continuous double helical structure, assembled by non-covalent building blocks. Built up solely by weak stacking interactions, this alternating tread stairs-like double helical assembly mimics the DNA double helix structure. Starting from a racemic mixture in aqueous solution, the ruthenium(II) polypyridyl complex forms two polymorphic structures of a left-handed double helical assembly of only the Λ-enantiomer. The stacking of the helices is different in both polymorphs: a crossed woodpile structure versus a parallel columnar stacking.
ISSN: 1433-7851
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Biochemistry, Molecular and Structural Biology Section
Molecular Imaging and Photonics
× corresponding author
# (joint) last author

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