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Title: Glucose and sucrose: hazardous fast-food for industrial yeast?
Authors: Verstrepen, Kevin ×
Iserentant, Dirk
Malcorps, Philippe
Derdelinckx, Guy
Van Dijck, Patrick
Winderickx, Joris
Pretorius, Isak S
Thevelein, Johan
Delvaux, Freddy #
Issue Date: Sep-2004
Series Title: Trends in biotechnology vol:22 issue:10 pages:531-7
Abstract: Yeast cells often encounter a mixture of different carbohydrates in industrial processes. However, glucose and sucrose are always consumed first. The presence of these sugars causes repression of gluconeogenesis, the glyoxylate cycle, respiration and the uptake of less-preferred carbohydrates. Glucose and sucrose also trigger unexpected, hormone-like effects, including the activation of cellular growth, the mobilization of storage compounds and the diminution of cellular stress resistance. In an industrial context, these effects lead to several yeast-related problems, such as slow or incomplete fermentation, 'off flavors' and poor maintenance of yeast vitality. Recent studies indicate that the use of mutants with altered responses to carbohydrates can significantly increase productivity. Alternatively, avoiding unnecessary exposure to glucose and sucrose could also improve the performance of industrial yeasts.
URI: 
ISSN: 0167-7799
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Microbiology and Biotechnology Section - miscellaneous
Molecular Physiology of Plants and Micro-organisms Section - miscellaneous
Centre for Food and Microbial Technology
Centre of Microbial and Plant Genetics
× corresponding author
# (joint) last author

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