Title: Combined Liver and Lung Transplantation With Extended Normothermic Lung Preservation in a Patient With End-Stage Emphysema Complicated by Drug-Induced Acute Liver Failure
Authors: Ceulemans, Laurens ×
Monbaliu, Diethard
Verslype, Chris
Van der Merwe, Schalk
Laleman, Wim
Vos, Robin
Neyrinck, Arne
Van Veer, Hans
De Leyn, Paul
Nevens, Frederik
Pirenne, Jacques
Verleden, Geert
Van Raemdonck, Dirk #
Issue Date: Oct-2014
Publisher: Munksgaard International Publishers
Series Title: American Journal of Transplantation vol:14 issue:10 pages:2412-2416
Article number: 10.1111/ajt.12856
Abstract: Isolated lung transplantation (LuTx) and liver transplantation are established treatments for irreversible lung and liver failure. Combined liver and lung transplantation (cLiLuTx) is a less common, but approved therapy of combined organ failure, mostly applied in patients suffering from progressive cystic fibrosis and advanced liver disease. We report a patient who was listed for LuTx due to end-stage chronic obstructive pulmonary disease and who developed drug-induced acute hepatic failure. The only therapeutic option was hyper-urgent cLiLuTx. To correct the poor coagulation in order to reduce the per-operative risk of bleeding, the liver was transplanted first. In anticipation of the longer lung preservation time, cold flushed lungs were preserved on a portable lung perfusion device for ex vivo normothermic perfusion for 11 h 15 min, transplanted sequentially off-pump, and reperfused after a total ex vivo time of 13 h 32 min and 16 h for the first and second lung, respectively. Ten months later, the patient is doing well and no rejection occurred. Normothermic ex vivo lung perfusion may help to prolong preservation time, facilitating long-distance transport and combined organ transplantation.
ISSN: 1600-6135
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Thoracic Surgery
Laboratory of Abdominal Transplantation
Department of Health and Technology - UC Leuven
Anesthesiology and Algology
× corresponding author
# (joint) last author

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