Title: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline
Authors: Da Cunha, Violette *
Davies, Mark R *
Douarre, Pierre-Emmanuel
Rosinski-Chupin, Isabelle
Margarit, Immaculada
Spinali, Sebastien
Perkins, Tim
Lechat, Pierre
Dmytruk, Nicolas
Sauvage, Elisabeth
Ma, Laurence
Romi, Benedetta
Tichit, Magali
Lopez-Sanchez, Maria-José
Descorps-Declere, Stéphane
Souche, Erika
Buchrieser, Carmen
Trieu-Cuot, Patrick
Moszer, Ivan
Clermont, Dominique
Maione, Domenico
Bouchier, Christiane
McMillan, David J
Parkhill, Julian
Telford, John L
Dougan, Gordan
Walker, Mark J
DEVANI Consortium
Holden, Matthew T G
Poyart, Claire
Glaser, Philippe ×
DEVANI Consortium #
Issue Date: 2014
Series Title: Nature communications vol:5 pages:4544
Article number: 10.1038/ncomms5544
Abstract: Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Due to the lack of epidemiological and genomic data, the reasons for this emergence are unknown. Here we show by comparative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates.
ISSN: 2041-1723
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
* (joint) first author
× corresponding author
# (joint) last author

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