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Title: Presence of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine in fermentations of Penicillium chrysogenum
Authors: Adriaens, Paul ×
Meesschaert, Boudewijn
Wuyts, W
Vanderhaeghe, Hubert
Eyssen, Hendrik #
Issue Date: Nov-1975
Publisher: Amer soc microbiology
Series Title: Antimicrobial Agents and Chemotherapy vol:8 issue:6 pages:638-42
Abstract: Cultures of Penicillium chrysogenum, growth with [(35)S]sulfate or labeled amino acids, were examined by ion-exchange chromatography for possible peptidic precursors of penicillin. A sulfur-containing compound, present in both the mycelial extracts and the culture filtrates, was eluted at the location of the synthetic lld-tripeptide delta-(l-alpha-aminoadipyl)-l-cysteinyl-d-valine. Since this compound was also labeled when the cultures were incubated with dl-[6-(14)C]alpha-aminoadipic acid, l-[3,3'-(3)H]cystine, or dl-[1-(14)C]valine, its identity with the synthetic lld-tripeptide can be accepted. No delta-(l-alpha-aminoadipyl)-l-cysteine or lll-tripeptide were detected. The implications of these findings for tripeptide and penicillin biosynthesis are discussed.
ISSN: 0066-4804
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Microbial and Molecular Systems - miscellaneous
Medicinal Chemistry (Rega Institute)
Technologiecluster Bioengineering Technologie
Bioengineering Technology TC, Campus Bruges
× corresponding author
# (joint) last author

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