Title: NO-dependent endothelial dysfunction in type II diabetes is aggravated by dyslipidemia and hypertension, but can be restored by angiotensin-converting enzyme inhibition and weight loss
Authors: Nevelsteen, Ines ×
Van den Bergh, An
Van der Mieren, Gerry
Vanderper, Annelies
Mubagwa, Kanigula
Bult, Hidde
Herijgers, Paul #
Issue Date: 2013
Publisher: S. Karger
Series Title: Journal of Vascular Research vol:50 issue:6 pages:486-97
Article number: 10.1159/000355221
Abstract: Insulin resistance, dyslipidemia and hypertension are independent mediators of endothelial dysfunction. It is incompletely defined whether dyslipidemia and hypertension in addition to diabetes mellitus type II (DMII), as seen in the metabolic syndrome (MS), worsen diabetes-induced endothelial dysfunction. Furthermore, it is unclear whether treatment influences endothelial dysfunction similarly in MS and DMII. Therefore, we studied vascular reactivity and the effect of in vivo treatment with angiotensin-converting enzyme inhibition (ACE-I) or hypocaloric diet in LDL receptor- and leptin-deficient (ob/ob), double knockout mice (DKO), featuring MS and in ob/ob mice with DMII.
ISSN: 1018-1172
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Experimental Cardiac Surgery
× corresponding author
# (joint) last author

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