Title: C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: A genome-wide meta-analysis
Authors: Diekstra, Frank P ×
Van Deerlin, Vivianna M
van Swieten, John C
Al-Chalabi, Ammar
Ludolph, Albert C
Weishaupt, Jochen H
Hardiman, Orla
Landers, John E
Brown, Robert H
van Es, Michael A
Pasterkamp, R Jeroen
Koppers, Max
Andersen, Peter M
Estrada, Karol
Rivadeneira, Fernando
Hofman, Albert
Uitterlinden, André G
Van Damme, Philip
Melki, Judith
Meininger, Vincent
Shatunov, Aleksey
Shaw, Christopher E
Leigh, P Nigel
Shaw, Pamela J
Morrison, Karen E
Fogh, Isabella
Chiò, Adriano
Traynor, Bryan J
Czell, David
Weber, Markus
Heutink, Peter
de Bakker, Paul I W
Silani, Vincenzo
Robberecht, Wim
van den Berg, Leonard H
Veldink, Jan H #
Issue Date: Jul-2014
Publisher: American Neurological Association
Series Title: Annals of Neurology vol:76 issue:1 pages:120-33
Article number: 10.1002/ana.24198
Abstract: Substantial clinical, pathological, and genetic overlap exists between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 inclusions have been found in both ALS and FTD cases (FTD-TDP). Recently, a repeat expansion in C9orf72 was identified as the causal variant in a proportion of ALS and FTD cases. We sought to identify additional evidence for a common genetic basis for the spectrum of ALS-FTD.
ISSN: 0364-5134
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Neurobiology (Vesalius Research Center)
× corresponding author
# (joint) last author

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