ITEM METADATA RECORD
Title: TRP channels in lower urinary tract dysfunction
Authors: Franken, Jan ×
Uvin, Pieter
De Ridder, Dirk
Voets, Thomas #
Issue Date: May-2014
Publisher: Scientific & Medical Division, Macmillan Press
Series Title: British Journal of Pharmacology vol:171 issue:10 pages:2537-51
Abstract: Lower urinary tract dysfunction (LUTd) represents a major healthcare problem. Although it is mostly not lethal, associated social disturbance, medical costs, loss of productivity and especially diminished quality of life should not be underestimated. Although more than 15% of people suffer from a form of LUTd to some extent, pathophysiology often remains obscure. In the past 20 years, transient receptor potential (TRP) channels have become increasingly important in this field of research. These intriguing ion channels are believed to be the main molecular sensors that generate bladder sensation. Therefore, they are intensely pursued as new drug targets for both curative and symptomatic treatment of different forms of LUTd. TRPV1 was the first of its class to be investigated. Actually, even before this channel was cloned, it had already been targeted in the bladder, with clinical trials of intravesical capsaicin instillations. Several other polymodally gated TRP channels, particularly TRPM8, TRPA1 and TRPV4, also appear to play a prominent role in bladder (patho)physiology. With this review, we provide a brief overview of current knowledge on the role of these TRP channels in LUTd and their potential as molecular targets for treatment.
ISSN: 0007-1188
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Ion Channel Research
Organ Systems (+)
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Franken et al. - 2014 - TRP channels in lower urinary tract dysfunction.pdf Published 509KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science